Whether solo, conditional saves, low levels, etc.?
Personally, I've recently been attempting a "no healing items in battle" challenge with this game, and so far I've been successful (I'm up to the 3Dazer quest now). Initially, the challenge was to not use any healing items at all, not even outside of battle (along with not using Egress Certificates or Teleport Amulets), but I had to change the rules somewhat when I got to the Halls of the Damned and past the Torture Maker specifically, as there was no way I was going to survive against the upcoming bosses (with Herasia and Baretta of all characters) without full recovery in between the battles. Sure, you had a few Full Recovery spots on the damaging tiles before the Torture Maker, but I'm sure you know why it isn't exactly a great idea to rely on those specific ones for actual full recovery. But so far, in battle, I have yet to use a single healing item.
It is not exactly a severe challenge, mind you. But it has been fun to try thus far, and it makes you really appreciate the usefulness of each character in your party, especially Sarah, Luciana, and Wendala.
We'll see later on if this challenge can even be possible against Rixian and the likes.